Until now, no tabular method has consistently outperformed classical supervised learning, which ignores these shifts.

Automated seizure detection is of great importance to epilepsy diagnosis and treatment.

The low-resource label analysis and representation visualization further illustrate the effectiveness of our pre-training strategy.

Survival analysis encompasses a broad range of methods for analyzing time-to-event data, with one key objective being the comparison of survival curves across groups. Traditional approaches for identifying clusters of survival curves often rely on computationally intensive bootstrap techniques to approximate the null hypothesis distribution. While effective, these methods impose significant computational burdens. In this work, we propose a novel approach that leverages the k-means and log-rank test to efficiently identify and cluster survival curves. Our method eliminates the need for computationally expensive resampling, significantly reducing processing time while maintaining statistical reliability. By systematically evaluating survival curves and determining optimal clusters, the proposed method ensures a practical and scalable alternative for large-scale survival data analysis. Through simulation studies, we demonstrate that our approach achieves results comparable to existing bootstrap-based clustering methods while dramatically improving computational efficiency. These findings suggest that the log-rank-based clustering procedure offers a viable and time-efficient solution for researchers working with multiple survival curves in medical and epidemiological studies.

This paper presents a probabilistic-graphical model that can be used to infer characteristics of instantaneous brain activity by jointly analyzing spatial and temporal dependencies observed in electroencephalograms (EEG). Specifically, we describe a factor-graph-based model with customized factor-functions defined based on domain knowledge, to infer pathologic brain activity with the goal of identifying seizure-generating brain regions in epilepsy patients. We utilize an inference technique based on the graph-cut algorithm to exactly solve graph inference in polynomial time. We validate the model by using clinically collected intracranial EEG data from 29 epilepsy patients to show that the model correctly identifies seizure-generating brain regions. Our results indicate that our model outperforms two conventional approaches used for seizure-onset localization (5-7% better AUC: 0.72, 0.67, 0.65) and that the proposed inference technique provides 3-10% gain in AUC ( 0.72, 0.62, 0.69) compared to sampling-based alternatives.

Large Language Models (LLMs) exhibit impressive capabilities, but remain susceptible to a growing spectrum of safety risks, including jailbreaks, toxic content, hallucinations, and bias. Existing defenses often address only a single threat type or resort to rigid outright rejection, sacrificing user experience and failing to generalize across diverse and novel attacks. This paper introduces Adversarial Scenario Extrapolation (ASE), a novel inference-time computation framework that leverages Chain-of-Thought (CoT) reasoning to simultaneously enhance LLM robustness and seamlessness. ASE guides the LLM through a self-generative process of contemplating potential adversarial scenarios and formulating defensive strategies before generating a response to the user query. Comprehensive evaluation on four adversarial benchmarks with four latest LLMs shows that ASE achieves near-zero jailbreak attack success rates and minimal toxicity, while slashing outright rejections to <4%. ASE outperforms six state-of-the-art defenses in robustness-seamlessness trade-offs, with 92-99% accuracy on adversarial Q&A and 4-10x lower bias scores. By transforming adversarial perception into an intrinsic cognitive process, ASE sets a new paradigm for secure and natural human-AI interaction.

Foundation models (FMs) promise to generalize medical imaging, but their effectiveness varies. It remains unclear how pre-training domain (medical vs. general), paradigm (e.g., text-guided), and architecture influence embedding quality, hindering the selection of optimal encoders for specific radiology tasks. To address this, we evaluate vision encoders from eight medical and general-domain FMs for chest X-ray analysis. We benchmark classification (pneumothorax, cardiomegaly) and segmentation (pneumothorax, cardiac boundary) using linear probing and fine-tuning. Our results show that domain-specific pre-training provides a significant advantage; medical FMs consistently outperformed general-domain models in linear probing, establishing superior initial feature quality. However, feature utility is highly task-dependent. Pre-trained embeddings were strong for global classification and segmenting salient anatomy (e.g., heart). In contrast, for segmenting complex, subtle pathologies (e.g., pneumothorax), all FMs performed poorly without significant fine-tuning, revealing a critical gap in localizing subtle disease. Subgroup analysis showed FMs use confounding shortcuts (e.g., chest tubes for pneumothorax) for classification, a strategy that fails for precise segmentation. We also found that expensive text-image alignment is not a prerequisite; image-only (RAD-DINO) and label-supervised (Ark+) FMs were among top performers. Notably, a supervised, end-to-end baseline remained highly competitive, matching or exceeding the best FMs on segmentation tasks. These findings show that while medical pre-training is beneficial, architectural choices (e.g., multi-scale) are critical, and pre-trained features are not universally effective, especially for complex localization tasks where supervised models remain a strong alternative.

Contrastive Language-Image Pre-training (CLIP) models have demonstrated superior performance across various visual tasks including medical image classification. However, fairness concerns, including demographic biases, have received limited attention for CLIP models. This oversight leads to critical issues, particularly those related to race and gender, resulting in disparities in diagnostic outcomes and reduced reliability for underrepresented groups. To address these challenges, we introduce AdFair-CLIP, a novel framework employing adversarial feature intervention to suppress sensitive attributes, thereby mitigating spurious correlations and improving prediction fairness. We conduct comprehensive experiments on chest X-ray (CXR) datasets, and show that AdFair-CLIP significantly enhances both fairness and diagnostic accuracy, while maintaining robust generalization in zero-shot and few-shot scenarios. These results establish new benchmarks for fairness-aware learning in CLIP-based medical diagnostic models, particularly for CXR analysis.

Large Language Models (LLMs) are increasingly demonstrating the potential to reach human-level performance in generating clinical summaries from patient-clinician conversations. However, these summaries often focus on patients' biology rather than their preferences, values, wishes, and concerns. To achieve patient-centered care, we propose a new standard for Artificial Intelligence (AI) clinical summarization tasks: Patient-Centered Summaries (PCS). Our objective was to develop a framework to generate PCS that capture patient values and ensure clinical utility and to assess whether current open-source LLMs can achieve human-level performance in this task. We used a mixed-methods process. Two Patient and Public Involvement groups (10 patients and 8 clinicians) in the United Kingdom participated in semi-structured interviews exploring what personal and contextual information should be included in clinical summaries and how it should be structured for clinical use. Findings informed annotation guidelines used by eight clinicians to create gold-standard PCS from 88 atrial fibrillation consultations. Sixteen consultations were used to refine a prompt aligned with the guidelines. Five open-source LLMs (Llama-3.2-3B, Llama-3.1-8B, Mistral-8B, Gemma-3-4B, and Qwen3-8B) generated summaries for 72 consultations using zero-shot and few-shot prompting, evaluated with ROUGE-L, BERTScore, and qualitative metrics. Patients emphasized lifestyle routines, social support, recent stressors, and care values. Clinicians sought concise functional, psychosocial, and emotional context. The best zero-shot performance was achieved by Mistral-8B (ROUGE-L 0.189) and Llama-3.1-8B (BERTScore 0.673); the best few-shot by Llama-3.1-8B (ROUGE-L 0.206, BERTScore 0.683). Completeness and fluency were similar between experts and models, while correctness and patient-centeredness favored human PCS.

Large language models (LLMs) hold great promise for medical applications and are evolving rapidly, with new models being released at an accelerated pace. However, benchmarking on large-scale real-world data such as electronic health records (EHRs) is critical, as clinical decisions are directly informed by these sources, yet current evaluations remain limited. Most existing benchmarks rely on medical exam-style questions or PubMed-derived text, failing to capture the complexity of real-world clinical data. Others focus narrowly on specific application scenarios, limiting their generalizability across broader clinical use. To address this gap, we present BRIDGE, a comprehensive multilingual benchmark comprising 87 tasks sourced from real-world clinical data sources across nine languages. It covers eight major task types spanning the entire continuum of patient care across six clinical stages and 20 representative applications, including triage and referral, consultation, information extraction, diagnosis, prognosis, and billing coding, and involves 14 clinical specialties. We systematically evaluated 95 LLMs (including DeepSeek-R1, GPT-4o, Gemini series, and Qwen3 series) under various inference strategies. Our results reveal substantial performance variation across model sizes, languages, natural language processing tasks, and clinical specialties. Notably, we demonstrate that open-source LLMs can achieve performance comparable to proprietary models, while medically fine-tuned LLMs based on older architectures often underperform versus updated general-purpose models. The BRIDGE and its corresponding leaderboard serve as a foundational resource and a unique reference for the development and evaluation of new LLMs in real-world clinical text understanding. The BRIDGE leaderboard: https://huggingface.co/spaces/YLab-Open/BRIDGE-Medical-Leaderboard